Low sodium versus normal sodium diets in systolic heart failure: systematic review and meta-analysis (Sep., 2012)
ABSTRACT:
Compared with a normal sodium diet, a low sodium diet significantly increases morbidity and mortality in systolic heart failure (HF).
Methods:
•A systematic review and meta-analysis of randomised trials OVID MEDLINE, PubMed, Excerpta Medica (Embase), the Cochrane Controlled Trials Register, Scopus, Web of Science and Google Scholar were searched up to April 2012.
•Two independent reviewers selected studies for inclusion on the basis of a randomised controlled trial design that included adults with systolic HF receiving a restricted salt diet or control diet and reporting mortality (all-cause, sudden death or HF-related) and HF-related hospitalisations.
•Descriptive and quantitative information was extracted from included studies.
•A random-effects model was used to compute pooled risk ratios (RR) for mortality and morbidity outcomes.
Results:
•Six randomised trials comparing low sodium diets (1.8 g/day) with normal sodium diets (2.8 g/d) in 2747 patients with systolic HF were identified.
•Compared with a normal sodium diet, a low sodium diet significantly increased all cause mortality (RR 1.95, 95% CI 1.66 to 2.29), sudden death (RR 1.72, 95% CI 1.21 to 2.44), death due to HF (RR 2.23, 95% CI 1.77 to 2.81) and HF readmissions (RR 2.10, 95% CI 1.67 to 2.64).
Reference:
http://www.mdlinx.com/nursing/news-article.cfm/4198136/45/heart-failure--systolic
