Association Between Consanguineous Marriages and Risk of Pre-Eclampsia(June 2010)
Association Between Consanguineous Marriages and Risk of Pre-Eclampsia
The objective of this hospital-based case–control study was to assess the association between consanguinity and risk of pre-eclampsia in Iran where the rate of consanguinity is relatively high. This trial included 171 healthy pregnant women and 140 pre-eclamptic women. The healthy control group was frequency matched with the age of the pre-eclamptic women. Control women had no history of pregnancies with pre-eclampsia.
The authors found the prevalence of consanguinity was 42.8 and 30.9% in cases and controls, respectively. In univariate analysis, the mean inbreeding coefficient for cases (α = 0.0218) was higher than that of controls (α = 0.0174), denoting a significant difference (p = 0.02). When family history was entered as a covariate in multivariate analysis, adjusted odds ratios (OR) revealed that the first cousin once removed (OR = 4.11, 95% CI 1.32–12.7, p = 0.014) increased the risk of pre-eclampsia, in comparison with unrelated marriages. This data suggests that consanguinity in terms of first cousin once removed seems to be associated with pre-eclampsia after controlling for maternal age and family history of pre-eclampsia. The authors suggested to proceed with further investigations adjusted for other confounding factors are needed to confirm this information.
REFERENCE:
http://www.springerlink.com/content/r4761w5578256765/
